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Cookie policy

This Cookie Policy explains how AVEO Pharmaceuticals, Inc. (“AVEO” or “our” or “we”) uses cookies and similar technologies to recognize you when you visit our websites and use our web applications. It explains what these technologies are and why we use them, as well as your rights to control our use of them.

To the extent that any information collected by the cookies or similar technologies, either on its own or in combination with other information, constitutes personal information as the term is used in our Privacy Policy, both our Privacy Policy and this Cookie Policy shall apply to the processing and transferring of such personal information.

What are Cookies?

A cookie is a piece of information contained in a very small text file that is stored on your computer. Cookies allow a website to identify a user’s device whenever that user returns to the website and are commonly used in order to make websites work more efficiently and enrich the user experience, as well as to provide information to the owners of the site.

Periodically, some pages on sites may use cookies for identification purposes. Such cookies are used for site registration and customization the next time you visit us. These cookies are set by us and are called first party cookies. We may also collect information about how you use the sites using cookies (and other similar technologies), as part of improving the content and functionality of the website. You should note that cookies cannot read data off of your hard drive. Your web browser may allow you to be notified when you are receiving a cookie, giving you the choice to accept it or not. You can also refuse all cookies by turning them off in your browser. By not accepting cookies, some pages may not fully function, and you may not be able to access certain information on the sites.

We may also use third-party cookies. Third-party cookies are created by domains that are not the sites (or domain) that you are visiting. These cookies are used for our marketing efforts, as well as to understand your browsing of the sites, for example, which page you visit or how long you stay on each page. These types of cookies are set by AVEO affiliates and/or vendors we are working with to enhance end-user experience or may be used to identify visitors to our sites.

We may also use internet tags such as “pixel tags,” which are small graphic files that allow us to monitor the use of our websites. A pixel tag can collect additional information such as IP address, URL, timestamp, browser type and the cookie identification number.

We may use independent advertising companies to provide ads on our behalf across the internet (“advertising company”). These advertising companies also help us analyze our advertising campaigns and the general usage patterns of visitors to our websites. This is primarily accomplished through the use of cookies and internet tags. Such companies may place these tags on our websites or on other sites.

“Do-Not-Track” is an optional browser setting that you can use to express your preferences regarding tracking by advertisers and other third parties. Please note, however, that our website does not have the capability to respond to “Do Not Track” signals received from web browsers at this time. We commit to user privacy by honoring Do Not Track (“DNT”) browser settings.

How to Control Cookies

You can control, opt-out, reject and/or delete cookies as you wish. You can delete all cookies that are already on your computer, and you can set most browsers to prevent them from being placed. If you do this, however, you may have to manually adjust some preferences every time you visit a site and some services and functionalities may not work. For more information about how to manage cookies, please visit https://www.aboutcookies.org/.

You may also control your online behavioral advertising preferences and opt-out from having your data processed by certain marketing companies by visiting http://www.youronlinechoices.com/ and http://optout.aboutads.info/. Please note, however, that managing these preferences will not turn off internet advertisements in general. You will still receive the same number of advertisements, but those advertisements will be less reflective of your interests, as indicated by your web browsing habits. In addition, please note that the opt-out preferences that you set using these tools may be nullified if you delete your cookies after setting them.

Main Cookies AVEO Uses

The table below is a list of the main cookies set by AVEO websites. Please note that we may from time to time modify or update our cookies. When that happens, we will update this list accordingly.

  • Strictly Necessary Cookies: These cookies are essential in order to enable you to move around the website and use its features, such as accessing secure areas of the website. Without these cookies, services you have asked for, cannot be provided.
  • Performance Cookies: These cookies collect information about how visitors use a website, for instance which pages visitors go to most often, and if they get error messages from web pages. These cookies do not collect information that identifies a visitor. All information these cookies collect is aggregated and, therefore, anonymous. It is only used to improve how a website works.
  • Functionality Cookies: These cookies allow the website to remember choices you make (such as your username, language or the region you are in) and provide enhanced, more personal features. For instance, a website may be able to provide you with local weather reports or traffic news by storing a cookie for the region in which you are currently located. These cookies can also be used to remember changes you have made to text size, fonts and other parts of webpages that you can customize. They may also be used to provide services you have asked for, such as watching a video or commenting on a blog. The information these cookies collect may be anonymized and they cannot track your browsing activity on other websites.
  • Targeting / Advertising Cookies: These cookies are used to deliver advertisements more relevant to you and your interests. They are also used to limit the number of times you see an advertisement as well as help measure the effectiveness of the advertising campaign. They are usually placed by advertising networks with the website operator’s permission. They remember that you have visited a website and this information is shared with other organizations such as advertisers. Quite often targeting or advertising cookies will be linked to site functionality provided by the other organization.

Purpose Classifications and Descriptions for each cookie in the chart below are provided by AVEO’s IT Department.

Contact Us

If you have any questions about this Cookie Policy, please call us at (857) 400-0101, send us an e-mail at [email protected], or contact us by postal mail at:

AVEO Pharmaceuticals, Inc.
Attention: Legal Department
30 Winter Street
Boston, MA 02108

Please allow up to four (4) weeks for us to reply.

Effective on: December 28, 2022
Last Modified on: April 18, 2023

INDICATIONS AND
IMPORTANT SAFETY INFORMATION

FOTIVDA® (tivozanib) is a prescription medicine used to treat adults with advanced kidney cancer (advanced renal cell carcinoma or RCC) that has been treated with 2 or more prior medicines and has come back or did not respond to treatment.

It is not known if FOTIVDA is safe and effective in children.

Possible serious side effects can occur with FOTIVDA. Call or see your healthcare provider right away if you develop:

High blood pressure (hypertension). High blood pressure may be severe, including a sudden, severe increase in your blood pressure (hypertensive crisis) that can lead to death. Your healthcare provider should check your blood pressure after 2 weeks and at least monthly, and may prescribe medicine to treat high blood pressure. You should check your blood pressure regularly and tell your healthcare provider if you have increased blood pressure or experience confusion, headaches, dizziness, chest pain, or shortness of breath.

Heart failure. Heart failure may be serious and sometimes lead to death. Your healthcare provider should check for symptoms of heart failure regularly, such as shortness of breath or swelling of your ankles.

Heart attack and blood clots in your veins or arteries. Blood clots may be serious and sometimes lead to death. Tell your healthcare provider or get emergency medical help right away if you have:

  • new chest pain or pressure
  • numbness or weakness on one side of your body
  • pain in your arms, back, neck or jaw
  • trouble talking
  • shortness of breath
  • sudden severe headache
  • vision changes
  • swelling in the arms or legs

Bleeding problems. Bleeding may be serious and sometimes lead to death. Report or get medical help right away if you have:

  • unusual bleeding from the gums
  • red or black stools (looks like tar)
  • menstrual bleeding or vaginal bleeding that is heavier than normal
  • bruises that happen without a known cause or get larger
  • headaches, feeling dizzy or weak
  • bleeding that is severe or you cannot control
  • coughing up blood or blood clots
  • pink or brown urine
  • vomiting blood or your vomit looks like “coffee grounds”
  • unexpected pain, swelling, or joint pain

Protein in your urine. Your healthcare provider should check your urine for protein before and during treatment.

Thyroid gland problems. Your healthcare provider should do blood tests to check your thyroid gland function before and during your treatment, and may prescribe medicine if you develop thyroid gland problems.

Risk of wound-healing problems. Wounds may not heal properly during treatment. Tell your healthcare provider if you plan to have surgery before starting or during treatment, including dental surgery.

  • You should stop taking FOTIVDA at least 24 days before planned surgery.
  • Your healthcare provider should tell you when you may start taking FOTIVDA again after surgery.

Reversible Posterior Leukoencephalopathy Syndrome (RPLS). RPLS is a condition that can happen. Tell your healthcare provider right away if you have headaches, seizures, confusion, blindness or changes in vision, or difficulty thinking.

Allergic reactions to tartrazine (FD&C Yellow No. 5). FOTIVDA contains a dye called FD&C Yellow No. 5 (tartrazine) that may cause allergic-type reactions, including bronchial asthma, in certain people. This occurs most often in people who also are allergic to aspirin.

The most common side effects of FOTIVDA include:

  • tiredness
  • diarrhea
  • decreased appetite
  • nausea
  • hoarseness
  • low levels of thyroid hormones
  • cough
  • mouth sores
  • decreased blood levels of salt (sodium) and phosphate
  • increased levels of lipase in the blood

Other side effects include vomiting and weakness or lack of energy. FOTIVDA may cause fertility problems in males and females, which may affect your ability to have a child.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with FOTIVDA if you have certain side effects.

These are not all of the possible side effects of FOTIVDA.

Before taking FOTIVDA, tell your healthcare provider about all your medical conditions, including if you:

  • have high blood pressure.
  • have a history of heart failure.
  • have a history of blood clots in your veins or arteries (types of blood vessels), including stroke, heart attack, or change in vision.
  • have bleeding problems.
  • have thyroid problems.
  • have liver problems.
  • have an unhealed wound.
  • plan to have surgery or have had recent surgery, including dental surgery. You should stop taking FOTIVDA at least 24 days before planned surgery.
  • are allergic to FD&C Yellow No.5 (tartrazine) or aspirin.
  • are pregnant or plan to become pregnant. FOTIVDA can harm your unborn baby. If you are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start treatment.
    • Use effective birth control (contraception) during treatment and for 1 month after your last dose.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • Tell your healthcare provider right away if you become pregnant or think you might be pregnant.

Tell your healthcare provider about all the medicine you take and any new medicine, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking FOTIVDA with certain other medicines may affect how FOTIVDA works.

To report SUSPECTED ADVERSE REACTIONS, contact AVEO Pharmaceuticals, Inc. at 1-833-FOTIVDA (1-833-368-4832) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see the Patient Information in the full Prescribing Information for FOTIVDA® (tivozanib).